Do you suffer from Polycystic Ovarian Syndrome, PCOS? If you have PCOS and are blessed to have children; do you lay awake at night wondering if your daughter will inherit PCOS too? If so, you’re not alone. One in five women around the world have PCOS and since the syndrome is hereditary; female and male offspring can inherit the syndrome too. I’m like you, I have PCOS and I lay awake at night wondering if my daughter will endure the same struggles as I did to become a Mom. Read about my PCOS Journey here. However, there is hope! Scientist have now isolated the cause of PCOS and now hope for a cure to one of the most common forms of infertility m
What Causes PCOS?
In a June 2018 study published in Nature Medicine, Dr. Paolo Giacobini, lead researcher at the French National Institue of Health and Medical, discovered a hormone called anti-Mullerian hormone (AMH) may cause PCOS to be triggered before birth, in utero while a child is still in the womb. Overexposure to the anti-Mullerian hormone before birth leads to both female and male children are born with the syndrome. Dr. Gaiacobini’s research concludes that women with PCOS have 30% more AMH than women without PCOS. Controlling the hormone can and may reverse PCOS in many women and make ovulation and periods regular again.
Surprisingly, Dr. Giacobini’s team not only isolated the cause of PCOS, but they also started experimenting on a possible cure for it too. The team used mice to experiment and found that increased AMH in your system leads to overstimulation of a certain cell in the brain called GnRH neurons. The GnRh neuron is responsible for the regulation on testosterone in one’s system. With overstimulation of GnRh neuron’s, testosterone increases and leads to excessive hair growth, which is a hallmark of PCOS.
Seeing this same effect of overstimulated GnRH neurons in mice with increased AMH, scientist proceeded to give the mice and IVF drug called Cetrorelix which decreased symptoms of PCOS. The study showed that Cetrorelix may treat and prevent PCOS from being passed down to the next generation. However, it is too early to see if Cetrorelix will be used for treatment.
PCOS in Both Men and Women
Research shows that PCOS, also knows as the Stein-Leventhal Syndrome has a genetic link and can be passed down from generation to generation in both men in women. In women, PCOS can cause a multitude of reproductive symptoms and health problems such as anovulation, irregular periods, cysts in ovaries, infertility, insulin resistance and an increase in developing heart disease and diabetes.
Male descendants who inherit PCOS / Stein-Leventhal Syndrome do not exhibit the same symptoms of females but have major health risks also. Health risks such as excessive sweating, early onset of male pattern baldness and excess hairiness. Like women, men also have insulin resistance, obesity, and increase risks of heart disease and diabetes.
As I researched this article and my own family medical history of PCOS. I, unfortunately, saw signs of PCOS in both my mother and father. My mother had 3 children but had cysts on her right ovary, as do I. A sister was not able to have children because of infertility. My mother also suffers from Diabetes and high Cholesterol.
My father and brother have classic male symptoms of male PCOS. Both have early onset of male hair loss. Both started balding in their early 30’s. My brother sweats profusely during any form of physical activity. It’s so bad that he needs a carry a towel. They both also have excessive body hair.
What a Cure for PCOS Could Bring
An obvious problem a cure for PCOS could solve is Infertility. But the reality is women suffering from PCOS suffer from other severe symptoms too. Severe symptoms can include:
- Ovarian Cysts – Cysts can get very large if left untreated. There have been reports of cysts as large as 17 inches and can destroy an ovary and fallopian tube if it’s not reduced. If one bursts, the pain is unreal!! I’ve had one burst and its worse than labor.
- Excessive Hair Loss – We all loose hair every day. But to loose so much that its very noticeable in your 20’s is devastating to a young woman.
- Missed Periods and BOOM Mega Period – Missing a period when you have PCOS is typical. I’ve gone around 100 days without a cycle and then Boom Mega Period hits and it’s awful!!! Talk about excessive bleeding with large blood clots accompanied with severe cramps and bloating. You literally have to wear a diaper all day and better call in sick because you’re going to have an accident at work.
- Ovarian Tumors – Cysts that are left unchecked can develop into Ovarian Tumors. Many women with PCOS are Ovarian Cancer Red Flags with your doctor. Regular checkups are required to monitor cysts in case they possibly develop into something else.
- Insulin Resistance– Insulin Resistance leads to a number of health problems such as prediabetes, weight gain and hard to loose weight.
The list of symptoms and how many of us women suffer from PCOS can be viewed in real pics of how women endure PCOS at 23 Pictures that Show the Reality of Living with PCOS.
Reality of PCOS
The reality of living with PCOS is harsh. The pic from 23 Pictures that Show the Reality of Living with PCOS really put it into perspective the seriousness of being diagnosed with PCOS. A diagnosis of PCOS should not be taken lightly. If you have a family history
I dont want my daughter to endure what I’m going through with PCOS. The thought of her suffering the same way as I have breaks my heart. My only consolation is that she is only 6 years old and maybe, just maybe their will be a cure for PCOS before she hits puberty.